Benefits of Glucosamine & Chondroitin

Over the past several decades, there has been a significant increase in knee and hip joint pain and osteoarthritis among the general population. Younger patients may have pain due to increased engagement in competitive sports, as well as an increase in recreation athletes who are not properly trained. Repetitive stresses on the joints can cause cartilage damage over time. Analgesics and nonsteroidal anti-inflammatory medications (NSAIDs) are commonly used to alleviate pain. However, they serve as symptomatic therapies. Long-term usage of non-steroidal
anti-inflammatory medicines has raised concerns among patients and clinicians due to potential harmful effects.

They are accused of not providing a remedy for joint pain and increasing the risk of unwanted outcomes. Glucosamine and chondroitin nutritional supplements are now often used to relieve joint pain. Research suggests that glucosamine has a substantial influence on stiffness by boosting glycosaminoglycan production and increase type II collagen expression in chondrocytes. It is also believed to prevent glycosaminoglycan and collagen degradation by down-regulating the production of inflammatory cytokines through decreased prostaglandin E2 synthesis, inhibition of nuclear factor kappa B (NFkB), and decreased expression of catabolic enzymes such as metalloproteinases.

Chondroitin is more beneficial for pain relief and improved physical performance through three primary mechanisms: anabolic action by encouraging the formation of extracellular matrix of cartilage, reduction of inflammatory mediators, and prevention of cartilage degradation.
Chondroitin has been shown in studies to inhibit the function of IL-1b (a factor that causes articular inflammation and cartilage deterioration), so acting as a chondroprotectant. Both chemicals have good safety profiles. Combination treatment with glucosamine and chondroitin is unquestionably a better approach for all people suffering from any kind of joint pain without causing serious side effects.